New NIH Parent Announcements and Review Criteria for Research Grant Applications

NIH recently provided updated information for 2019 submissions.

First is the announcement of changes to R01, R03, and R21 Parent Announcements which can be found on the NIH website at

Beginning 01/05/2019:

R01      Clinical Trial Required                PA-19-055

R01      Clinical Trail not allowed             PA-19-056

R03      Clinical Trial not allowed             PA-19-052

R21      Clinical Trial Required                PA-19-054

R21      Clinical Trail not allowed             PA-19-053

If you are submitting an application in 2019 you will want to familiarize yourself with some changes to the instructions and review criteria which can be found in the following announcement:

Second, for due dates on or after January 25, 2019, updates include changes to:

  • The rigor of the prior research, formerly Scientific Premise
  • Inclusion reporting
  • Protections for human subjects

Summary of Updates – please refer to the full notice for additional information.

Revisions to the application guide ( will be available as of November 25, 2018.


Table courtesy of Rachel Charney, Population Research Institute